Drugs With the Worst Detox | Palm Beach Institute
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What Drugs Have the Worst Detoxes?

There are many mind-altering substances to which a person could become addicted, each offering its own risks and dangerous. However, it goes without saying that some substances are more addictive and dangerous than others. Additionally, while the use and misuse of certain substances is more dangerous than others, there’s also the fact that detoxing from certain substances can be particularly risky as well. Therefore, the following will explain the purpose of detoxification and name the drugs that are known for having the most difficult or dangerous detox process.

What Exactly is the Purpose of Detox Treatment?

When it comes to addiction, there are two sides to the disease: the physical and the psychological. Before an individual can overcome the psychological aspects of dependency — which is essential in order to achieve long-lasting sobriety — he or she must overcome physical dependency, which is the purpose of detox treatment. When an individual begins detox treatment, he or she typically resides in a special detox facility while receiving care and being monitored by physicians and other treatment providers. The purpose of detoxing in a facility is to ensure that an individual’s detoxification progresses smoothly without endangering the patient’s life; moreover, detoxing under supervision means the patient’s symptoms can be treated with so-called “comfort medications” in order to alleviate some of the severity of withdrawal. In short, the purpose of detox treatment is to cleanse an individual’s body of toxins and other harmful substances, helping him or her to overcome physical dependency in order to begin receiving treatment for psychological dependency.

Heroin Detox

heroin detox

Considered by most to be the most addictive drug there is, heroin is an opioid that’s derived from the opium obtained from a special poppy. The substance bonds with the brain’s opiate receptors, causing a sedative effect while relaxing the individual and alleviating any pain or physical discomfort. The drug also causes a spike in the levels of certain neurochemicals that activate the reward and pleasure circuits in the brain; when deprived of the drug, individuals who are addicted to heroin experience intense withdrawals that make it difficult to detoxify. During heroin detox treatment, individuals sometimes receive medications like methadone, Suboxone or Subutex (buprenorphine), or even mild benzodiazepines to alleviate some of the discomforts of withdrawal. Unfortunately, many heroin addicts experience post-acute withdrawal symptoms for months or even years after becoming sober; however, detox treatment helps with the most severe symptoms and helps individuals become ready to receive heroin addiction treatments.

Alcohol Detox

alcohol detox

One could call alcoholism the original addiction as it allowed us to gain a better understanding of substance abuse and addiction as a whole. Alcohol is a very highly addictive substance that’s difficult for alcoholics to give up. Compared to most other substances, the physical dependency an alcoholic forms with alcohol is incredibly intense, making alcohol detox potentially dangerous. In fact, alcoholics are typically discouraged from detoxing on their own without some form of professional supervision due to the risk of several life-threatening conditions that are sometimes brought on by an alcoholic’s sudden cessation of alcohol. Specifically, conditions like delirium tremens, alcoholic hallucinosis, alcohol withdrawal syndrome, and a condition known as “wet brain” can occur when individuals detox from alcohol without supervision. In instances of severe alcoholism, many patients will receive medications in order to make them safer during detoxification.

Benzodiazepine Detox

Benzodiazepine Detox

Similar to alcohol, benzodiazepines are a substance to which individuals can develop incredibly strong physical dependencies. For those who are unfamiliar with them, benzodiazepines are essentially a form of tranquilizers or strong sedatives that are frequently prescribed for the treatment of anxiety, insomnia, epilepsy and similar conditions, social phobias, and prior to surgical procedures to help calm individuals down. Unfortunately, their effects make benzodiazepines a popular type of substance for abuse. Due to their moderate to intense effects on the central nervous system, habitual use and misuse of benzodiazepines are incredibly dangerous with the drug being notoriously difficult from which to detox. When an individual dependent on benzodiazepines ceases consumption suddenly, he or she is at risk of experiencing severe withdrawal symptoms, which can even include seizures; as such, it’s crucial that those addicted to benzodiazepines detox is in supervised, medical environment.

Crystal Methamphetamine Detox


While there are other drugs — such as heroin — that are equally as addictive, crystal methamphetamine, or crystal meth for short, is dangerous for more reasons than as a recreational drug. In terms of its effects, crystal meth is a stimulant with its greatest effects being to the central nervous system. During World War II, the man-made substance was often given to soldiers to help them to stay away during extended or prolonged combat. Nowadays, crystal meth is made in patch-make, improvised home laboratory using a variety of volatile, dangerous chemicals that often cause explosions. The effects of crystal meth last for many hours with individuals frequently going on “binges” during which they’ll continue to use crystal meth for days on end. When under the influence of meth, neurochemical levels are exceedingly high, especially with regard to dopamine; however, the high dissipates quickly, causing dopamine levels to plummet. Additionally, long-term meth use is known to cause brain damage as well as neurotoxicity. Methamphetamine detoxification is considered one of the most difficult detoxes for a number of reasons. Some of the most common symptoms of a methamphetamine detox include depression, inability to feel happiness or pleasure, insomnia and irregular sleep patterns, paranoia, hallucinations, anxiety, physical pain throughout the body, agitation, and intense cravings.

Find a Medical Detox Program at the Palm Beach Institute

There are many treatment and recovery options available to those who are in need. At the Palm Beach Institute, our goal is to match anyone who is suffering from addiction with the programs that best address his or her needs. If you or someone you love would like to begin living a life of health and sobriety, call the Palm Beach Institute at 855-960-5456 for a free consultation and assessment. Our specialists are available anytime, day or night, to help you or your loved one. Nobody should have to continue suffering from an addiction to alcohol or drugs.

13 Responses to “What Drugs Have the Worst Detoxes?”

  1. I’m going to have to say that Effexor withdrawal is worse than the hardest illegal drugs.

  2. I agree w I think @Jack. Effexor is probably the worst drug I’ve ever been on. And the detox was the worst I’ve ever experienced. Every single time I moved my eyes or turned my body slightly it was like I was shocked by the paddles over and over and over. My mind felt like I did a lethal dose of dope. (Methamphetamine) it took forever for it all to wear off. Literally 6-8 months. Effexor should be banned. Myself, my brother, and my Father all went through the same experience. Painkiller withdrawal is a long ways under EFFEXOR. But this is the mentally hardest and physically painful detox off a long time use. (All prescribed for surgery and chronic pain)

  3. Jack, I couldn’t agree more. I have detoxed from heroin multiple times, and Effexor twice. Effexor was worse. I thought I was either going to lose my mind or kill myself. Or both. I’m clean now, and although I still struggle with depression, I will never take an antidepressant ever again.

  4. I just stop taking effexor I had bad withdrawing my doktor did not help me or told me have BSD it would be
    What’s wrong with them ? Berit

  5. I think Baclofen has the worst psychical withdrawal(but without pain)… it is like phenibut, but it have CL(chloride) witch is in all benzos 🙁

  6. I got off effexor it’s now 5 month ago I talk to you about it I now feel fine ! Don’t give up ! Berit norlen

    • Deja Holley

      Great inspiration, keep on track with your sobriety. (:

  7. BB lee

    I would have to say methadone is by far the worst demon of all. N it’s such a LONG withdrawal. I’ve been on for 15 years n am finally tapering off. I’m now at 19mgs which is a very low dose. I’m in total withdrawal from 3am-10am-ish. It’s probably a good year before I will ever feel normal once I’m totally off. I tend to panick to n sometimes feel it’s just to hard. Good luck to all who experience addiction. N stay strong. Ur not alone. Thanks for letting me share!

  8. I have been on both effexor and methamphetamines and I agree that the withdraw was really hard, however methadone is by far the absolute worst I’ve ever went through, every move hurts the entire body… The bone and muscle pain is horrific. And I’ve only went four days without it because of a virus and unable to keep a single thing down, I am going to start a slow detox when the virus is gone, I am now super afraid of this…. It’s not worth it…. If you are reading this I suggest you do anything you can to avoid getting hooked on this medication, I am afraid of heights and seriously thought of jumping off a ten story building to free myself from the pain. I was given a 2mg injection of dalaudid and it didn’t help at all!!!

  9. Berit Norlen

    Effexor is terrible the 2first month After I stopped ok ! Then hell broke loose for 3-4 .month then it got better but I still don’t feel ok 12 month later !

  10. I’ve been on effector for close to a year and every time I try to go off I feel like I’m dying. if my doctor would have told me how bad it was I never would have started it. I’m trying again now and already I feel like I’m being electrocuted in my brain every five seconds. it definitely should be in the top 4

  11. Berit Norlen

    After 12 month since I stop taking effexor I still feel depressed and have anxiety when I wake up in the morning (?) Then after I get up and have coffee I am ok ?do anybody else have the same experience ?? Berit norlen

  12. Patrick Bodine

    Do you have bad withdrawal from suboxone and is it easy to quit?


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