Sedative Withdrawal

Americans, by and large, are no strangers to being unable to get a good night’s sleep. According to the U.S. Centers for Disease Control and Prevention, there are an estimated 50 to 70 million adults in the United States currently suffering from a sleep-related disorder. 

In the years before the rapid and widespread rise of prescription drug abuse and the deadly overdoses that often follow, benzodiazepines, drugs like Valium, Klonopin, and Xanax that are primarily used to treat anxiety, were the go-to medications for treating insomnia and other sleep disorders.

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However, as the high risk of addiction and abuse these drugs carried with them became more and more apparent, prescriptions for benzos to treat sleep issues saw a sharp decline in favor of non-benzodiazepine sleep aids like Ambien, Lunesta, and Sonata, otherwise known as “z drugs.”

These sedatives seemed like the perfect answer to benzodiazepine medications, working in almost the same way as benzos do in terms of how they alter the brain, but with a significantly lower risk of dependency and other adverse effects.  

In fact, z drugs were so heavily embraced as the safe alternative to benzos that, according to the FDA, there were about three million people taking Lunesta in 2013, and as of 2016, Ambien was ranked among the top 20 most prescribed drugs in the country.

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Ironically, it’s the common association of non-benzodiazepine sedatives as the “safe” option when it comes to treating insomnia and other sleep disorders that make them dangerously easy to misuse to the point of physical and psychological dependence and significant potential harm. 

More than 21 million Americans have reported as having abused non-benzo prescription sedatives at least once in their lives, often overlook concerning side effects of many sedatives, such as depression, general disorientation, sleep-walking, sleep-eating, even sleep-driving in some cases, as well as significant memory loss. 

Many people will abuse these sedatives recreationally, mixing them with alcohol and other substances, using them to come down from amphetamine highs, or even just forcing themselves to stay awake in order to achieve hallucinatory effects.

But even to people who are, initially at least, taking these sedatives for their intended purpose, they still pose a substantial risk, in part because the majority of them are only meant to be used for a short period of time. Ambien has a short treatment period of 1 to 2 weeks or less. Per FDA recommendation, doctors should prescribe the lowest dosage of Ambien as a safety measure as well as monitor patients for any physical and psychological changes, especially beyond the intended treatment period.
Similarly, Lunesta use is usually limited to short treatment periods of 1 to 2 weeks or less. The FDA recommended starting dose is 1 milligram for both men and women at bedtime as directed.

The reason for these limitations is that people can find themselves building up a tolerance to z drugs within just days of regular and consistent use. And as someone grows to tolerate these sedatives, requiring more to achieve the same effects, they are more likely to readily abuse them, taking larger doses for longer periods of time, since they are considered safe and not carrying any serious consequences.

It only takes a brief period of regular misuse for someone to quickly become dependent on them, especially if crushed and snorted or injected as opposed to taken in tablet form. An individual abusing Lunesta can develop a full-blown addiction in just two weeks.

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How Sedatives Affect the Brain

As previously mentioned, non-benzodiazepine sedatives work in much the same way as their benzo counterparts, binding themselves to a neurotransmitter in the brain called gamma-aminobutyric acid, or GABA. 

GABA is a chemical in the brain that is responsible for regulating how the body responds to fear, anxiety, and stress. What GABA does is block these nerve impulses from reaching the brain. Essentially, GABA’s job is to help keep you calm.

Sedatives Affect the Brain function

What benzos do is to potentiate the action of GABA inhibitory neurons in the brain, flooding it in order to create a significantly stronger feeling of sedation, which is how it counteracts anxiety and can be used to get high. 

While z drugs also affect the levels of GABA in the brain, they are much more selective. Instead of binding with any GABA receptors and increasing them, non-benzo sedatives like Ambien target specific GABA receptors that are specifically related to initiating sleep and creating more of those. 

Because of this, the user will generally feel less intense effects and not as much of a potentially dangerous “sleep hangover” the next morning that comes with using benzos to treat insomnia.

Even though these sedatives are less dangerous because they do not alter the effect of GABA in the brain as much as benzos do, regular abuse of z drugs beyond the recommended dosage is still enough to make the brain produce less GABA on its own and become dependent on the sedative to provide it. 

One of the most serious and potentially deadly situations that can happen during sedative withdrawal is when someone tries to stop taking a medication like Ambien or Lunesta all at once. This may not seem particularly dangerous since they’re just sleep aids, but it should be avoided at all costs.

When heavy users abruptly stop taking sedatives altogether, disrupts the levels in the brain, while the brain tries to compensate for this (sudden) change, and this can result in life-threatening seizures, though uncommon.

In order to avoid this danger, it is highly recommended that someone attempting a sedative detox do so in the care of a professional medical detox center, where a doctor can place them on a tapering schedule, slowly reducing the dosage until it is safe to stop taking it.

What You Can Expect from Sedative Withdrawal

Because z drugs affect the brain in much the same way as benzos do, they share many of the same withdrawal symptoms of drugs like Ativan, Librium, or Klonopin. However, what is usually the most intense symptom of sedative withdrawal is unique to these z drugs: rebound insomnia.

Once the sedatives have left your system and the body struggles to handle the loss of GABA, those in withdrawal can expect bouts of rebound insomnia. 

The difference between the insomnia someone might have been experiencing before taking sedatives and rebound insomnia is that rebound insomnia will be significantly worse and more intense than the sleep issues they were dealing with prior to using and can have the effect of total sleeplessness for sometimes days on end.

Other common symptoms to expect over the course of sedative withdrawal include:

  • Anxiety and panic attacks
  • Mood swings
  • Periods of uncontrollable crying
  • Nausea
  • Vomiting
  • Increased sweating
  • Extreme fatigue
  • General insomnia and rebound insomnia
  • Tremors
  • Abdominal pain
  • Vivid and upsetting dreams and nightmares
  • Elevated heart rate

Although not as common as the above symptoms, some people may also experience sedative withdrawal symptoms such as hallucinations, delirium, and seizures.

Sedative Withdrawal Timeline

While there is an established sedative withdrawal timeline that will match up with most people’s detoxing experience, when it comes to determining the sedative withdrawal timeline for a given individual, there are a variety of factors to consider, including general ones like:

  • How long someone has been abusing this sedative
  • How much of it they were taking
  • How they were taking it (as a tablet, crushing and snorting it, injecting it, etc.)
  • Whether they were abusing sedatives at the same time as other drugs or alcohol
  • If they have a history of previous addictions
  • If they have a co-occurring disorder or other mental health issues
  • The overall state of their current health
  • Whether they are detoxing on a tapering schedule

It also matters which sedative they were abusing. For example, extended-release Ambien is meant to release its effects over a long span of time, and so it has a much longer half-life, which means it could as long as several days before withdrawal symptoms appear, and a much longer withdrawal timeline in general.

On the other hand, Lunesta is only meant to induce sleep, not maintain it, so its half-life is only six hours, which means that someone could start experiencing symptoms in as little as 12 hours after their last dose.

Keeping these important factors in mind, someone’s sedative withdrawal timeline will usually resemble the following:

12 TO 48 HOURS

Z drugs with a shorter half-life will have withdrawal symptoms appearing within the first 12 to 24 hours of the last use, while other ones that take longer to leave the body might not appear until a couple of days later. These early symptoms will include mood swings, anxiety, and rebound insomnia.

7 TO 10 DAYS

Depending on the sedative, over the course of the following days into the next week, both the psychological and physical symptoms will have appeared and eventually reach their peak, with worsened rebound insomnia. This period is when people are usually their most vulnerable to relapsing.


Either by roughly the second or third week, the majority of the symptoms will either have disappeared or become much easier to manage. However, symptoms of anxiety, mild depression, and rebound insomnia will most likely still be present.


Somewhere between the third week and a month, the symptoms of sedative withdrawal will have passed, though in some cases, symptoms of insomnia and anxiety can persist several months after stopping the use of sedatives.

There is also the possibility of experiencing what is known as post-acute withdrawal syndrome, or PAWS. PAWS is a secondary withdrawal phase that can persist months after someone has detoxed from sedatives and include symptoms such as random bouts of drug cravings, unstable moods, suicidal thoughts, and issues with coordination and balance.

What are the Sedative Withdrawal Treatment Steps?

The best way to treat sedative withdrawal that both ensures your safety and gives you the highest chance of a successful detox without relapsing is by doing it at a professional medical detox center. 

This way you can avoid the dangers of detoxing at home, as you will be monitored around the clock by experienced medical staff who can provide medication to help ease withdrawal symptoms and make the process as painless as possible.

Sedative Withdrawal Treatment Steps

Getting sedative withdrawal treatment at a medical detox center also means that a doctor can put you on a tapering schedule and slowly wean you off of the z drug you’ve become dependent on until it is safe to stop using it without the risk of triggering a seizure. 

Once the withdrawal period is over, the next step should be entering into a recovery treatment program. While your body will have flushed out all of the sedatives, this doesn’t do anything to curb the addictive behaviors that led to dependency in the first place.

In order to avoid relapse and truly address the issues behind addiction, a rehabilitation treatment program is crucial to the recovery process and being able to maintain long-term sobriety.

Typically, a client will work with their counselor and the facility staff to customize a treatment plan that will work best for them, choosing from a variety of treatment programs, including support groups, counseling, anddifferent types oftherapies.

If you or a loved one is battling an addiction to sedatives, alcohol or other drugs, The Palm Beach Institute can provide the help you need, offering medical detox treatment with a seamless transition to ongoing care in a recovery treatment program. Call (855) 960-5456 now to speak with one of our addiction specialists, or contact us online for more information.